Investigate the Role of Glutathione S Transferase (GST) Polymorphism in Development of Hypertension in UAE Population
نویسندگان
چکیده
BACKGROUND GST is a family of enzymes that are important in protection of the body against oxidative stress. OBJECTIVES Investigate the association between GSTT1 and GSTM1 polymorphism and hypertension. MATERIALS AND METHODS GSTT1 and GSTM1 genotypes were detected by PCR. The fragments were then analyzed by agarose gel electrophoresis. RESULTS There is no significant association between GSTT1 & GSTM1 polymorphism and hypertension (OR = 2.4, P > 0.05 and OR = 1.6, P > 0.05) CONCLUSIONS GSTT1 & GSTM1 polymorphism can be considered a risk factor for hypertension.
منابع مشابه
Class-Pi of Glutathione S-Transferases
Class-Pi of glutathione s-transferases (GST-Pi) is the specific form of GSTs that are known to participate particularly in the mechanisms of resistance to drugs and carcinogens. This class of the enzyme is referred to as class-P or class-Pi or class π. The accepted terminology in this review article is class-Pi. In this article following a brief description of identified molecular forms of GSTs...
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